7Q7K
JAK2 in complex with 4-(2-amino-8-methoxyquinazolin-6-yl)phenol
Summary for 7Q7K
Entry DOI | 10.2210/pdb7q7k/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol (3 entities in total) |
Functional Keywords | jak2, janus kinase 2, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37721.58 |
Authors | Rowland, P. (deposition date: 2021-11-09, release date: 2022-02-02, Last modification date: 2024-05-01) |
Primary citation | Wellaway, C.R.,Baldwin, I.R.,Bamborough, P.,Barker, D.,Bartholomew, M.A.,Chung, C.W.,Dumpelfeld, B.,Evans, J.P.,Fazakerley, N.J.,Homes, P.,Keeling, S.P.,Lewell, X.Q.,McNab, F.W.,Morley, J.,Needham, D.,Neu, M.,van Oosterhout, A.J.M.,Pal, A.,Reinhard, F.B.M.,Rianjongdee, F.,Robertson, C.M.,Rowland, P.,Shah, R.R.,Sherriff, E.B.,Sloan, L.A.,Teague, S.,Thomas, D.A.,Wellaway, N.,Wojno-Picon, J.,Woolven, J.M.,Coe, D.M. Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism. J.Med.Chem., 65:633-664, 2022 Cited by PubMed: 34928601DOI: 10.1021/acs.jmedchem.1c01765 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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