7Q71

The crystallographic structure of the Ligand Binding domain of the NR7 nuclear receptor from the amphioxus Branchiostoma lanceolatum

7Q71 の概要

• エントリーDOI: 10.2210/pdb7q71/pdb
• 分子名称: Nuclear hormone receptor 7, CHLORIDE ION, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, ligand binding domain, amphioxus, heterodimerization, transcription
• 由来する生物種: Branchiostoma lanceolatum (Common lancelet, Amphioxus lanceolatum)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26834.82

構造登録者

Billas, I.M.L.,McEwen, A.G.,Hazemann, I.,Moras, D.,Laudet, V. (登録日: 2021-11-09, 公開日: 2022-09-14, 最終更新日: 2024-01-31)

主引用文献

Beinsteiner, B.,Markov, G.V.,Bourguet, M.,McEwen, A.G.,Erb, S.,Patel, A.K.M.,El Khaloufi El Khaddar, F.Z.,Lecroisey, C.,Holzer, G.,Essabri, K.,Hazemann, I.,Hamiche, A.,Cianferani, S.,Moras, D.,Laudet, V.,Billas, I.M.L.
A novel nuclear receptor subfamily enlightens the origin of heterodimerization.
Bmc Biol., 20:217-217, 2022

PubMed Abstract: Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerization, derives from functional studies undertaken in classical model animals. It has become evident, however, that a deeper understanding of these molecular functions requires uncovering how these characteristics originated and diversified during evolution, by looking at more species. In particular, the comprehension of how dimerization evolved from ancestral homodimers to a more sophisticated state of heterodimers has been missing, due to a too narrow phylogenetic sampling. Here, we experimentally and phylogenetically define the evolutionary trajectory of nuclear receptor dimerization by analyzing a novel NR7 subgroup, present in various metazoan groups, including cnidarians, annelids, mollusks, sea urchins, and amphioxus, but lost in vertebrates, arthropods, and nematodes.

PubMed: 36199108
DOI: 10.1186/s12915-022-01413-0

実験手法

X-RAY DIFFRACTION (2 Å)