7Q5O

Bromodomain-containing 2 BD2 in complex with the inhibitor CRCM5484

7Q5O の概要

• エントリーDOI: 10.2210/pdb7q5o/pdb
• 関連するPDBエントリー: 7Q3F
• 分子名称: Bromodomain-containing protein 2, 2-[[11-ethanoyl-4-(furan-2-ylmethyl)-3-oxidanylidene-8-thia-4,6,11-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),5-trien-5-yl]sulfanyl]-~{N}-(2-methylpyridin-3-yl)ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: epigenetic, inhibition, inhibitor, selectivity, complex, bdii, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13622.70

構造登録者

Carrasco, K.,Betzi, S.,Morelli, X. (登録日: 2021-11-04, 公開日: 2022-04-20, 最終更新日: 2024-01-31)

• 主引用文献: Carrasco, K.,Montersino, C.,Derviaux, C.,Saez-Ayala, M.,Hoffer, L.,Restouin, A.,Castellano, R.,Casassa, J.,Roche, P.,Pasquier, E.,Combes, S.,Morelli, X.,Collette, Y.,Betzi, S.; CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation; J.Med.Chem., 65:5660-5674, 2022; DOI: 10.1021/acs.jmedchem.1c02168

実験手法

X-RAY DIFFRACTION (1.519 Å)