7Q5I

A glucose-based molecular rotor probes the catalytic site of glycogen phosphorylase.

This is a non-PDB format compatible entry.

Summary for 7Q5I

• Entry DOI: 10.2210/pdb7q5i/pdb
• Descriptor: Glycogen phosphorylase, muscle form, 2-cyano-3-[4-(dimethylamino)phenyl]-~{N}-[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]propanamide, CARBONATE ION, ... (5 entities in total)
• Functional Keywords: glycogen phosphorylase, inhibitor, type 2 diabetes, molecular rotors, sugar binding protein
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 98286.07

Authors

Neofytos, D.D.,Chrysina, E.D. (deposition date: 2021-11-03, release date: 2022-03-02, Last modification date: 2024-01-31)

• Primary citation: Minadakis, M.P.,Mavreas, K.F.,Neofytos, D.D.,Paschou, M.,Kogkaki, A.,Athanasiou, V.,Mamais, M.,Veclani, D.,Iatrou, H.,Venturini, A.,Chrysina, E.D.,Papazafiri, P.,Gimisis, T.; A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function.; Org.Biomol.Chem., 20:2407-2423, 2022; PubMed: 35119451; DOI: 10.1039/d1ob02211c

Experimental method

X-RAY DIFFRACTION (1.8 Å)