7Q4A
Toxoplasma gondii PRP4K kinase domain (L715F) bound to altiratinib
Summary for 7Q4A
| Entry DOI | 10.2210/pdb7q4a/pdb |
| Descriptor | Non-specific serine/threonine protein kinase, Altiratinib, GLYCEROL, ... (6 entities in total) |
| Functional Keywords | spliceosome, kinase inhibitor, splicing inhibition, splicing |
| Biological source | Toxoplasma gondii |
| Total number of polymer chains | 2 |
| Total formula weight | 87031.65 |
| Authors | Swale, C.,Bellini, V.,Bowler, M. (deposition date: 2021-10-29, release date: 2022-08-03, Last modification date: 2024-01-31) |
| Primary citation | Swale, C.,Bellini, V.,Bowler, M.W.,Flore, N.,Brenier-Pinchart, M.P.,Cannella, D.,Belmudes, L.,Mas, C.,Coute, Y.,Laurent, F.,Scherf, A.,Bougdour, A.,Hakimi, M.A. Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase. Sci Transl Med, 14:eabn3231-eabn3231, 2022 Cited by PubMed: 35921477DOI: 10.1126/scitranslmed.abn3231 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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