7Q3J

Computationally designed thioredoxin subjected to stability optimizing mutations.

Summary for 7Q3J

• Entry DOI: 10.2210/pdb7q3j/pdb
• Related: 5j7d
• Descriptor: MM9, GLYCEROL (3 entities in total)
• Functional Keywords: de-novo protein design, deep mutational scanning, stability, screening, de novo protein
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 26939.01

Authors

Norrild, R.K.,Johansson, K.E.,O'Shea, C.,Lindorff-Larsen, K.,Winther, J.R.,Morth, J.P. (deposition date: 2021-10-27, release date: 2022-11-16, Last modification date: 2024-02-07)

• Primary citation: Norrild, R.K.,Johansson, K.E.,O'Shea, C.,Morth, J.P.,Lindorff-Larsen, K.,Winther, J.R.; Increasing protein stability by inferring substitution effects from high-throughput experiments.; Cell Rep Methods, 2:100333-100333, 2022; PubMed: 36452862; DOI: 10.1016/j.crmeth.2022.100333

Experimental method

X-RAY DIFFRACTION (1.9 Å)