7Q1B
Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with Quisinostat
Summary for 7Q1B
Entry DOI | 10.2210/pdb7q1b/pdb |
Descriptor | Histone deacetylase DAC2, ZINC ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | epigenetics, trypanosoma cruzi, histone deacetylase, dac2, pathogen, hydrolase |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 1 |
Total formula weight | 51038.92 |
Authors | Marek, M.,Ramos-Morales, E.,Romier, C. (deposition date: 2021-10-18, release date: 2021-12-15, Last modification date: 2024-01-31) |
Primary citation | Marek, M.,Ramos-Morales, E.,Picchi-Constante, G.F.A.,Bayer, T.,Norstrom, C.,Herp, D.,Sales-Junior, P.A.,Guerra-Slompo, E.P.,Hausmann, K.,Chakrabarti, A.,Shaik, T.B.,Merz, A.,Troesch, E.,Schmidtkunz, K.,Goldenberg, S.,Pierce, R.J.,Mourao, M.M.,Jung, M.,Schultz, J.,Sippl, W.,Zanchin, N.I.T.,Romier, C. Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Rep, 37:110129-110129, 2021 Cited by PubMed: 34936867DOI: 10.1016/j.celrep.2021.110129 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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