7PZU

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

7PZU の概要

• エントリーDOI: 10.2210/pdb7pzu/pdb
• 分子名称: UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, (2S,4S)-N-((3R,5R)-1-(cyclopropanecarbonyl)-5-((3-fluoro-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamido)methyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: elastase, inhibitor, fluoroproline, zinc-binding group, antibiotic, multidrug-resistant gram-negative bacteria, hydrolase
• 由来する生物種: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35542.52

構造登録者

Ryan, M.D.,Pallin, T.D.,Lamers, M.B.A.C.,Leonard, P.M. (登録日: 2021-10-13, 公開日: 2022-11-02, 最終更新日: 2024-01-31)

• 主引用文献: Ryan, M.D.,Pallin, T.D.,Mullins, T.,Blench, T.,Fraser, I.,Dallow, J.,Ahmed, N.,Ellwood, C.,Gaines, S.,Flores, J.,Blackwell, Y.,Garcia, C.T.,Spence, G.,Reeve, A.,Panchal, T.,Dominguez-Fernandez, B.,Leonard, P.M.,Lamers, M.B.A.C.,Arduin, A.,Fotinou, C.,Gancia, E.,Clark, D.E.,Bush, E.,Betts, J.,Richards, C.,Rea-Davies, T.,Keefe, A.D.,Zhang, Y.,Soutter, H.T.,Centrella, P.A.,Clark, M.A.,Cuozzo, J.W.,Dumelin, C.E.,Habeshian, S.,Hunt, A.,Sigel, E.A.,Troast, D.M.,DeJonge, B.L.M.; LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria; To Be Published,

実験手法

X-RAY DIFFRACTION (2.15 Å)