7PX4

Crystal structure of the adenosine A2A receptor (A2A-PSB1-bRIL) in complex with preladenant conjugate PSB-2113

7PX4 の概要

• エントリーDOI: 10.2210/pdb7px4/pdb
• 分子名称: Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, Preladenant conjugate PSB-2113, ... (7 entities in total)
• 機能のキーワード: gpcr, membrane protein, a2a, g protein-coupled receptor, adenosine receptor, preladenant
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60595.07

構造登録者

Claff, T.,Klapschinski, T.A.,Tiruttani Subhramanyam, U.K.,Vaassen, V.J.,Schlegel, J.G.,Vielmuth, C.,Voss, J.H.,Labahn, J.,Muller, C.E. (登録日: 2021-10-07, 公開日: 2022-03-02, 最終更新日: 2024-01-31)

• 主引用文献: Claff, T.,Klapschinski, T.A.,Tiruttani Subhramanyam, U.K.,Vaassen, V.J.,Schlegel, J.G.,Vielmuth, C.,Voss, J.H.,Labahn, J.,Muller, C.E.; Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates.; Angew.Chem.Int.Ed.Engl., 61:e202115545-e202115545, 2022; PubMed: 35174942; DOI: 10.1002/anie.202115545

実験手法

X-RAY DIFFRACTION (2.25 Å)