7PW7

Human SMG1-9 kinase complex bound to a SMG1 inhibitor

Summary for 7PW7

• Entry DOI: 10.2210/pdb7pw7/pdb
• EMDB information: 13677
• Descriptor: SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1, Protein SMG9, INOSITOL HEXAKISPHOSPHATE, ... (6 entities in total)
• Functional Keywords: complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 456870.44

Authors

Langer, L.M.,Conti, E. (deposition date: 2021-10-06, release date: 2021-12-01)

• Primary citation: Langer, L.M.,Bonneau, F.,Gat, Y.,Conti, E.; Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.; Elife, 10:-, 2021; PubMed: 34698635; DOI: 10.7554/eLife.72353

Experimental method

ELECTRON MICROSCOPY (3.59 Å)