7PUC

CARM1 in complex with EML981

7PUC の概要

• エントリーDOI: 10.2210/pdb7puc/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, methyl 6-[4-[[~{N}-[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: protein arginine n-methyltransferase, prmt4, carm1, inhibitor, transcription
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 166058.58

構造登録者

Marechal, N.,Cura, V.,Bonnefond, L.,Troffer-Charlier, N.,Cavarelli, J. (登録日: 2021-09-29, 公開日: 2022-04-06, 最終更新日: 2024-01-31)

• 主引用文献: Iannelli, G.,Milite, C.,Marechal, N.,Cura, V.,Bonnefond, L.,Troffer-Charlier, N.,Feoli, A.,Rescigno, D.,Wang, Y.,Cipriano, A.,Viviano, M.,Bedford, M.T.,Cavarelli, J.,Castellano, S.,Sbardella, G.; Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.; J.Med.Chem., 65:11574-11606, 2022; PubMed: 35482954; DOI: 10.1021/acs.jmedchem.2c00252

実験手法

X-RAY DIFFRACTION (2.19 Å)