7PRY

Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with COVOX-45 and beta-6 Fabs

7PRY の概要

• エントリーDOI: 10.2210/pdb7pry/pdb
• 分子名称: COVOX-45 Fab heavy chain, COVOX-45 Fab light chain, Beta-6 Fab heavy chain, ... (6 entities in total)
• 機能のキーワード: sars-cov-2 alpha variant, beta variant, gamma variant, delta variant, b.1.1.7, b.1.351, p.1, b.1.617.2, antibody, receptor-binding-domain, spike, neutralisation, viral protein/immune system, viral protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 239587.09

構造登録者

Zhou, D.,Ren, J.,Stuart, D.I. (登録日: 2021-09-22, 公開日: 2021-12-15, 最終更新日: 2024-01-31)

• 主引用文献: Liu, C.,Zhou, D.,Nutalai, R.,Duyvesteyn, H.M.E.,Tuekprakhon, A.,Ginn, H.M.,Dejnirattisai, W.,Supasa, P.,Mentzer, A.J.,Wang, B.,Case, J.B.,Zhao, Y.,Skelly, D.T.,Chen, R.E.,Johnson, S.A.,Ritter, T.G.,Mason, C.,Malik, T.,Temperton, N.,Paterson, N.G.,Williams, M.A.,Hall, D.R.,Clare, D.K.,Howe, A.,Goulder, P.J.R.,Fry, E.E.,Diamond, M.S.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R.; The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.; Cell Host Microbe, 30:53-, 2022; PubMed: 34921776; DOI: 10.1016/j.chom.2021.11.013

実験手法

X-RAY DIFFRACTION (3.1 Å)