7PR7
Crystal structure of human heparanase in complex with covalent inhibitor VL166
Summary for 7PR7
Entry DOI | 10.2210/pdb7pr7/pdb |
Descriptor | Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | glycoside hydrolase, carbohydrate, glucuronidase, gh79, heparan sulfate |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 53520.67 |
Authors | Wu, L.,Armstrong, Z.,Davies, G.J. (deposition date: 2021-09-21, release date: 2022-08-03, Last modification date: 2024-01-31) |
Primary citation | de Boer, C.,Armstrong, Z.,Lit, V.A.J.,Barash, U.,Ruijgrok, G.,Boyango, I.,Weitzenberg, M.M.,Schroder, S.P.,Sarris, A.J.C.,Meeuwenoord, N.J.,Bule, P.,Kayal, Y.,Ilan, N.,Codee, J.D.C.,Vlodavsky, I.,Overkleeft, H.S.,Davies, G.J.,Wu, L. Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119:e2203167119-e2203167119, 2022 Cited by PubMed: 35881786DOI: 10.1073/pnas.2203167119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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