7PR7

Crystal structure of human heparanase in complex with covalent inhibitor VL166

Summary for 7PR7

• Entry DOI: 10.2210/pdb7pr7/pdb
• Descriptor: Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: glycoside hydrolase, carbohydrate, glucuronidase, gh79, heparan sulfate
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 53520.67

Authors

Wu, L.,Armstrong, Z.,Davies, G.J. (deposition date: 2021-09-21, release date: 2022-08-03, Last modification date: 2024-01-31)

• Primary citation: de Boer, C.,Armstrong, Z.,Lit, V.A.J.,Barash, U.,Ruijgrok, G.,Boyango, I.,Weitzenberg, M.M.,Schroder, S.P.,Sarris, A.J.C.,Meeuwenoord, N.J.,Bule, P.,Kayal, Y.,Ilan, N.,Codee, J.D.C.,Vlodavsky, I.,Overkleeft, H.S.,Davies, G.J.,Wu, L.; Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.; Proc.Natl.Acad.Sci.USA, 119:e2203167119-e2203167119, 2022; PubMed: 35881786; DOI: 10.1073/pnas.2203167119

Experimental method

X-RAY DIFFRACTION (1.52 Å)