7PMT

Human Cyclophilin D in complex with N-[(5-ethyl-4-oxo-1,2,3,4,5,6- hexahydro-1,5-benzodiazocin-8-yl)methyl]-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide

Summary for 7PMT

Entry DOI	10.2210/pdb7pmt/pdb
Related	7NHB 7NMR 7O02 7O3G 7OGI
Descriptor	Peptidyl-prolyl cis-trans isomerase F, mitochondrial, DIMETHYL SULFOXIDE, ~{N}-[(5-ethyl-4-oxidanylidene-1,2,3,6-tetrahydro-1,5-benzodiazocin-8-yl)methyl]-7-methyl-2-oxidanylidene-1,3-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide, ... (4 entities in total)
Functional Keywords	cyclophilin d ppiase, isomerase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18270.92
Authors	Silva, D.O.,Graedler, U.,Bandeiras, T.M. (deposition date: 2021-09-02, release date: 2022-09-14, Last modification date: 2026-04-01)
Primary citation	Silva, D.O.,Freitas, M.C.,Malta, C.F.,Martins, M.T.,Sousa, P.M.,Matias, P.M.,Schwarz, D.,Ventura, M.R.,Gradler, U.,Bandeiras, T.M. Structure-based design of pyrazole derivatives targeting the human Cyclophilin D binding site Int.J.Biol.Macromol., :151496-, 2026 Cited by DOI: 10.1016/j.ijbiomac.2026.151496 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.98 Å)

Structure validation