7PLL

Structure of the murine cortactin C-SH3 domain in complex with a Pyk2 proline-rich ligand

Summary for 7PLL

• Entry DOI: 10.2210/pdb7pll/pdb
• NMR Information: BMRB: 50901
• Descriptor: Src substrate cortactin, Pyk2-PRR2 peptide (2 entities in total)
• Functional Keywords: sh3 domain, cortactin, pyk2, signaling, cancer, cell invasion
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 8997.06

Authors

Sokolik, C.G.,Samson, A.O.,Gil-Henn, H.,Chill, J.H. (deposition date: 2021-08-31, release date: 2022-07-13, Last modification date: 2024-06-19)

• Primary citation: Twafra, S.,Sokolik, C.G.,Sneh, T.,Srikanth, K.D.,Meirson, T.,Genna, A.,Chill, J.H.,Gil-Henn, H.; A novel Pyk2-derived peptide inhibits invadopodia-mediated breast cancer metastasis.; Oncogene, 42:278-292, 2023; PubMed: 36258022; DOI: 10.1038/s41388-022-02481-w

Experimental method

SOLUTION NMR