7PJM

Crystal Structure of Ivosidenib-resistant IDH1 variant R132C S280F in complex with NADPH and Ca2+/2-Oxoglutarate

7PJM の概要

• エントリーDOI: 10.2210/pdb7pjm/pdb
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, 2-OXOGLUTARIC ACID, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 146661.74

構造登録者

Reinbold, R.,Rabe, P.,Abboud, M.I.,Schofield, C.J. (登録日: 2021-08-24, 公開日: 2022-07-13, 最終更新日: 2024-01-31)

• 主引用文献: Reinbold, R.,Hvinden, I.C.,Rabe, P.,Herold, R.A.,Finch, A.,Wood, J.,Morgan, M.,Staudt, M.,Clifton, I.J.,Armstrong, F.A.,McCullagh, J.S.O.,Redmond, J.,Bardella, C.,Abboud, M.I.,Schofield, C.J.; Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.; Nat Commun, 13:4785-4785, 2022; PubMed: 35970853; DOI: 10.1038/s41467-022-32436-4

実験手法

X-RAY DIFFRACTION (2.1 Å)