7PJH

Crystal structure of the human spliceosomal maturation factor AAR2 bound to the RNAse H domain of PRPF8

7PJH の概要

• エントリーDOI: 10.2210/pdb7pjh/pdb
• 分子名称: Protein AAR2 homolog, Pre-mRNA-processing-splicing factor 8 (3 entities in total)
• 機能のキーワード: spliceosomal maturation, pre-mrna splicing, human aar2, human prpf8, splicing
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75390.62

構造登録者

Preussner, M.,Santos, K.,Heroven, A.C.,Alles, J.,Heyd, F.,Wahl, M.C.,Weber, G. (登録日: 2021-08-24, 公開日: 2022-11-02, 最終更新日: 2024-01-31)

• 主引用文献: Preussner, M.,Santos, K.F.,Alles, J.,Heroven, C.,Heyd, F.,Wahl, M.C.,Weber, G.; Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8.; Acta Crystallogr D Struct Biol, 78:1373-1383, 2022; PubMed: 36322420; DOI: 10.1107/S2059798322009755

実験手法

X-RAY DIFFRACTION (2.35 Å)