7PIV

Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution.

7PIV の概要

• エントリーDOI: 10.2210/pdb7piv/pdb
• 関連するPDBエントリー: 7PIU
• EMDBエントリー: 13453 13454
• 分子名称: Melanocortin receptor 4, NDP-alpha-MSH (other names Afamelanotide; Scenesse), Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (8 entities in total)
• 機能のキーワード: gpcr, melanocortin-4 receptor, melanocortin receptors, setmelanotide, ndp-alpha-msh, alpha-18 msh, antagonism, agonism, appetite regulation, anti-obesity treatment, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 145001.24

構造登録者

Heyder, N.A.,Schmidt, A.,Kleinau, G.,Hilal, T.,Scheerer, P. (登録日: 2021-08-23, 公開日: 2021-11-17)

• 主引用文献: Heyder, N.A.,Kleinau, G.,Speck, D.,Schmidt, A.,Paisdzior, S.,Szczepek, M.,Bauer, B.,Koch, A.,Gallandi, M.,Kwiatkowski, D.,Burger, J.,Mielke, T.,Beck-Sickinger, A.G.,Hildebrand, P.W.,Spahn, C.M.T.,Hilger, D.,Schacherl, M.,Biebermann, H.,Hilal, T.,Kuhnen, P.,Kobilka, B.K.,Scheerer, P.; Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.; Cell Res., 31:1176-1189, 2021; PubMed: 34561620; DOI: 10.1038/s41422-021-00569-8

実験手法

ELECTRON MICROSCOPY (2.86 Å)