7PGU

Autoinhibited structure of human neurofibromin isoform 2 stabilized by Zinc.

Summary for 7PGU

• Entry DOI: 10.2210/pdb7pgu/pdb
• EMDB information: 13396
• Descriptor: Neurofibromin, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ZINC ION, ... (4 entities in total)
• Functional Keywords: neurofibromin, cancer, gap, ras, neurofibromatosis type 1, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 641086.15

Authors

Naschberger, A.,Baradaran, R.,Carroni, M.,Rupp, B. (deposition date: 2021-08-15, release date: 2021-11-17, Last modification date: 2021-11-24)

• Primary citation: Naschberger, A.,Baradaran, R.,Rupp, B.,Carroni, M.; The structure of neurofibromin isoform 2 reveals different functional states.; Nature, 599:315-319, 2021; PubMed: 34707296; DOI: 10.1038/s41586-021-04024-x

Experimental method

ELECTRON MICROSCOPY (3.3 Å)