7PCN
BurG (holo) in complex with gonyenediol (14), trigonic acid (6) and DMS: Biosynthesis of cyclopropanol rings in bacterial toxins
Summary for 7PCN
Entry DOI | 10.2210/pdb7pcn/pdb |
Related | 6AQJ |
Descriptor | Ketol-acid reductoisomerase, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | pathogens, natural products, toxins, biosynthesis, catalysis, lyase |
Biological source | Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264) |
Total number of polymer chains | 2 |
Total formula weight | 79636.48 |
Authors | Trottmann, F.,Ishida, K.,Ishida, M.,Kries, H.,Groll, M.,Hertweck, C. (deposition date: 2021-08-03, release date: 2022-08-10, Last modification date: 2024-01-31) |
Primary citation | Trottmann, F.,Ishida, K.,Ishida-Ito, M.,Kries, H.,Groll, M.,Hertweck, C. Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nat.Chem., 14:884-890, 2022 Cited by PubMed: 35906404DOI: 10.1038/s41557-022-01005-z PDB entries with the same primary citation |
Experimental method |
Structure validation
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