7PCM

BurG (holo) in complex with (Z)-2,3-dihydroxy-6-methyl-hept-2-enoate (13): Biosynthesis of cyclopropanol rings in bacterial toxins

Summary for 7PCM

• Entry DOI: 10.2210/pdb7pcm/pdb
• Related: 6AQJ
• Descriptor: Ketol-acid reductoisomerase, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: pathogens, natural products, toxins, biosynthesis, catalysis, lyase
• Biological source: Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
• Total number of polymer chains: 2
• Total formula weight: 79232.88

Authors

Trottmann, F.,Ishida, K.,Ishida, M.,Kries, H.,Groll, M.,Hertweck, C. (deposition date: 2021-08-03, release date: 2022-08-10, Last modification date: 2024-01-31)

• Primary citation: Trottmann, F.,Ishida, K.,Ishida-Ito, M.,Kries, H.,Groll, M.,Hertweck, C.; Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.; Nat.Chem., 14:884-890, 2022; PubMed: 35906404; DOI: 10.1038/s41557-022-01005-z

Experimental method

X-RAY DIFFRACTION (2.05 Å)