7PCG
BurG (holo) in complex with cyclopropane-1,1-dicarboxylate (7): Biosynthesis of cyclopropanol rings in bacterial toxins
Summary for 7PCG
| Entry DOI | 10.2210/pdb7pcg/pdb |
| Related | 6AQJ |
| Descriptor | Ketol-acid reductoisomerase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, MAGNESIUM ION, ... (6 entities in total) |
| Functional Keywords | pathogens, natural products, toxins, biosynthesis, catalysis, lyase |
| Biological source | Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264) |
| Total number of polymer chains | 2 |
| Total formula weight | 79301.85 |
| Authors | Trottmann, F.,Ishida, K.,Ishida, M.,Kries, H.,Groll, M.,Hertweck, C. (deposition date: 2021-08-03, release date: 2022-08-10, Last modification date: 2024-01-31) |
| Primary citation | Trottmann, F.,Ishida, K.,Ishida-Ito, M.,Kries, H.,Groll, M.,Hertweck, C. Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nat.Chem., 14:884-890, 2022 Cited by PubMed: 35906404DOI: 10.1038/s41557-022-01005-z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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