7PB2

Crystal structure of JDI TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (VVVGADGVGK)

Summary for 7PB2

• Entry DOI: 10.2210/pdb7pb2/pdb
• Descriptor: MHC class I antigen, Beta-2-microglobulin, KRAS G12D peptide (VVVGADGVGK), ... (5 entities in total)
• Functional Keywords: hla, t cell receptor, kras, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 189950.50

Authors

Coles, C.H.,Karuppiah, V.,Robinson, R.A. (deposition date: 2021-07-30, release date: 2022-07-20, Last modification date: 2024-10-23)

• Primary citation: Poole, A.,Karuppiah, V.,Hartt, A.,Haidar, J.N.,Moureau, S.,Dobrzycki, T.,Hayes, C.,Rowley, C.,Dias, J.,Harper, S.,Barnbrook, K.,Hock, M.,Coles, C.,Yang, W.,Aleksic, M.,Lin, A.B.,Robinson, R.,Dukes, J.D.,Liddy, N.,Van der Kamp, M.,Plowman, G.D.,Vuidepot, A.,Cole, D.K.,Whale, A.D.,Chillakuri, C.; Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen; Nat Commun, 13:5333-, 2022; DOI: 10.1038/s41467-022-32811-1

Experimental method

X-RAY DIFFRACTION (3.41 Å)