7P51

CRYSTAL STRUCTURE OF THE SARS-COV-2 MAIN PROTEASE COMPLEXED WITH FRAGMENT F01

Summary for 7P51

Entry DOI	10.2210/pdb7p51/pdb
Related	7NTS 7NTT
Descriptor	3C-like proteinase, SODIUM ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	3clpro, main protease, sars-cov-2, 2019-ncov, inhibitor, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	1
Total formula weight	34346.51
Authors	Hanoulle, X.,Moschidi, D. (deposition date: 2021-07-13, release date: 2021-10-06, Last modification date: 2024-01-31)
Primary citation	Cantrelle, F.X.,Boll, E.,Brier, L.,Moschidi, D.,Belouzard, S.,Landry, V.,Leroux, F.,Dewitte, F.,Landrieu, I.,Dubuisson, J.,Deprez, B.,Charton, J.,Hanoulle, X. NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment. Angew.Chem.Int.Ed.Engl., 60:25428-25435, 2021 Cited by PubMed: 34570415 DOI: 10.1002/anie.202109965 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.474 Å)

Structure validation