7P0W

Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing thymine opposite to lesion)

7P0W の概要

• エントリーDOI: 10.2210/pdb7p0w/pdb
• 分子名称: N-glycosylase/DNA lyase, DNA (5'-D(*TP*TP*TP*(PED)P*TP*TP*TP*CP*T)-3'), DNA (5'-D(*AP*GP*AP*AP*AP*TP*AP*AP*A)-3'), ... (6 entities in total)
• 機能のキーワード: 8-oxoguanine dna glycosylase, agog, pyrococcus abyssi, trapped double-stranded dna intermediate, hydrolase
• 由来する生物種: Pyrococcus abyssi (strain GE5 / Orsay); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 33601.42

構造登録者

Coste, F.,Goffinont, S.,Flament, D.,Castaing, B. (登録日: 2021-06-30, 公開日: 2022-07-13, 最終更新日: 2024-01-31)

• 主引用文献: Franck, C.,Stephane, G.,Julien, C.,Virginie, G.,Martine, G.,Norbert, G.,Fabrice, C.,Didier, F.,Josef, S.M.,Bertrand, C.; Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing.; Nucleic Acids Res., 50:11072-11092, 2022; PubMed: 36300625; DOI: 10.1093/nar/gkac932

実験手法

X-RAY DIFFRACTION (1.12 Å)