7OY6

Crystal structure of human DYRK1A in complex with ARN25068

7OY6 の概要

• エントリーDOI: 10.2210/pdb7oy6/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}4-(3-cyclopropyl-1~{H}-pyrazol-5-yl)-~{N}2-(phenylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine (3 entities in total)
• 機能のキーワード: inhibitor, complex, gsk-3b, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42225.71

構造登録者

Tripathi, S.K.,Balboni, B.,Demuro, S.,DiMartino, R.,Ortega, J.,Girotto, S.,Cavalli, A. (登録日: 2021-06-23, 公開日: 2022-03-02, 最終更新日: 2024-01-31)

• 主引用文献: Demuro, S.,Sauvey, C.,Tripathi, S.K.,Di Martino, R.M.C.,Shi, D.,Ortega, J.A.,Russo, D.,Balboni, B.,Giabbai, B.,Storici, P.,Girotto, S.,Abagyan, R.,Cavalli, A.; ARN25068, a versatile starting point towards triple GSK-3 beta /FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.; Eur.J.Med.Chem., 229:114054-114054, 2022; PubMed: 34959172; DOI: 10.1016/j.ejmech.2021.114054

実験手法

X-RAY DIFFRACTION (2.38 Å)