7OXZ
VDR complex with a side-chain hydroxylated derivative of lithocholic acid
Summary for 7OXZ
Entry DOI | 10.2210/pdb7oxz/pdb |
Descriptor | Vitamin D3 receptor A, Nuclear receptor coactivator 1, (3R,6R)-6-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptane-1,3-diol, ... (4 entities in total) |
Functional Keywords | nuclear recptor, agonist, transcription |
Biological source | Danio rerio (Zebrafish) More |
Total number of polymer chains | 2 |
Total formula weight | 36299.49 |
Authors | Rochel, N. (deposition date: 2021-06-23, release date: 2021-09-01, Last modification date: 2024-01-31) |
Primary citation | Gonzalez, C.M.,Gaikwad, S.,Lasanta, G.,Loureiro, J.,Nilsson, N.,Peluso-Iltis, C.,Rochel, N.,Mourino, A. Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR). Bioorg.Chem., 115:105202-105202, 2021 Cited by PubMed: 34339974DOI: 10.1016/j.bioorg.2021.105202 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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