7OXQ

Crystal structure of HIV-1 reverse transcriptase with a double stranded DNA in complex with fragment 048 at the transient P-pocket.

Summary for 7OXQ

• Entry DOI: 10.2210/pdb7oxq/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, Gag-Pol polyprotein, DNA (28-MER), ... (6 entities in total)
• Functional Keywords: reverse transcriptase, rt-dna complex, rt sliding, transferase-dna complex, p-1 complex, p51, p66, transferase
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); More
• Total number of polymer chains: 8
• Total formula weight: 264746.17

Authors

Martinez, S.E.,Singh, A.K.,Das, K. (deposition date: 2021-06-22, release date: 2021-12-08, Last modification date: 2024-01-31)

• Primary citation: Singh, A.K.,Martinez, S.E.,Gu, W.,Nguyen, H.,Schols, D.,Herdewijn, P.,De Jonghe, S.,Das, K.; Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening.; Nat Commun, 12:7127-7127, 2021; PubMed: 34880240; DOI: 10.1038/s41467-021-27409-y

Experimental method

X-RAY DIFFRACTION (3.3 Å)