7OXQ
Crystal structure of HIV-1 reverse transcriptase with a double stranded DNA in complex with fragment 048 at the transient P-pocket.
Summary for 7OXQ
Entry DOI | 10.2210/pdb7oxq/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, Gag-Pol polyprotein, DNA (28-MER), ... (6 entities in total) |
Functional Keywords | reverse transcriptase, rt-dna complex, rt sliding, transferase-dna complex, p-1 complex, p51, p66, transferase |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 8 |
Total formula weight | 264746.17 |
Authors | Martinez, S.E.,Singh, A.K.,Das, K. (deposition date: 2021-06-22, release date: 2021-12-08, Last modification date: 2024-01-31) |
Primary citation | Singh, A.K.,Martinez, S.E.,Gu, W.,Nguyen, H.,Schols, D.,Herdewijn, P.,De Jonghe, S.,Das, K. Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening. Nat Commun, 12:7127-7127, 2021 Cited by PubMed: 34880240DOI: 10.1038/s41467-021-27409-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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