7OXQ

Crystal structure of HIV-1 reverse transcriptase with a double stranded DNA in complex with fragment 048 at the transient P-pocket.

7OXQ の概要

• エントリーDOI: 10.2210/pdb7oxq/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, Gag-Pol polyprotein, DNA (28-MER), ... (6 entities in total)
• 機能のキーワード: reverse transcriptase, rt-dna complex, rt sliding, transferase-dna complex, p-1 complex, p51, p66, transferase
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 264746.17

構造登録者

Martinez, S.E.,Singh, A.K.,Das, K. (登録日: 2021-06-22, 公開日: 2021-12-08, 最終更新日: 2024-01-31)

• 主引用文献: Singh, A.K.,Martinez, S.E.,Gu, W.,Nguyen, H.,Schols, D.,Herdewijn, P.,De Jonghe, S.,Das, K.; Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening.; Nat Commun, 12:7127-7127, 2021; PubMed: 34880240; DOI: 10.1038/s41467-021-27409-y

実験手法

X-RAY DIFFRACTION (3.3 Å)