7OWG

human DEPTOR in a complex with mutant human mTORC1 A1459P

7OWG の概要

• エントリーDOI: 10.2210/pdb7owg/pdb
• EMDBエントリー: 13097
• 分子名称: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, DEP domain-containing mTOR-interacting protein, ... (4 entities in total)
• 機能のキーワード: kinase, pikk, mtor, cancer-associated mutation, deptor, partial inhibitor, cancer, pdz, non-canonical pdz binding, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 519046.25

構造登録者

Heimhalt, M.,Berndt, A.,Wagstaff, J.,Anandapadamanaban, M.,Perisic, O.,Maslen, S.,McLaughlin, S.,Yu, W.-H.,Masson, G.R.,Boland, A.,Ni, X.,Yamashita, K.,Murshudov, G.N.,Skehel, M.,Freund, S.M.,Williams, R.L. (登録日: 2021-06-18, 公開日: 2021-09-08, 最終更新日: 2022-02-23)

• 主引用文献: Heimhalt, M.,Berndt, A.,Wagstaff, J.,Anandapadamanaban, M.,Perisic, O.,Maslen, S.,McLaughlin, S.,Yu, C.W.,Masson, G.R.,Boland, A.,Ni, X.,Yamashita, K.,Murshudov, G.N.,Skehel, M.,Freund, S.M.,Williams, R.L.; Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.; Elife, 10:-, 2021; PubMed: 34519269; DOI: 10.7554/eLife.68799

実験手法

ELECTRON MICROSCOPY (4.7 Å)