7OVI
Protein kinase MKK7 in complex with phenethyltriazole-substituted pyrazolopyrimidine
Summary for 7OVI
Entry DOI | 10.2210/pdb7ovi/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 7, 1-[(3~{R})-3-[4-azanyl-3-[1-(2-phenylethyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one (3 entities in total) |
Functional Keywords | inhibitor, complex, mkk7, kinase, triazole, click-chemistry, cuacc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36592.38 |
Authors | Kleinboelting, S.,Buehrmann, M.,Mueller, M.P.,Rauh, D. (deposition date: 2021-06-15, release date: 2022-07-20, Last modification date: 2024-01-31) |
Primary citation | Gehrtz, P.,Marom, S.,Buhrmann, M.,Hardick, J.,Kleinbolting, S.,Shraga, A.,Dubiella, C.,Gabizon, R.,Wiese, J.N.,Muller, M.P.,Cohen, G.,Babaev, I.,Shurrush, K.,Avram, L.,Resnick, E.,Barr, H.,Rauh, D.,London, N. Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries. J.Med.Chem., 65:10341-10356, 2022 Cited by PubMed: 35912476DOI: 10.1021/acs.jmedchem.1c02206 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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