7OVD
Human soluble adenylyl cyclase in complex with the inhibitor TDI10229
Summary for 7OVD
Entry DOI | 10.2210/pdb7ovd/pdb |
Descriptor | Adenylate cyclase type 10, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... (6 entities in total) |
Functional Keywords | soluble adenylyl cyclase, adcy10, signaling enzyme, class iii cyclase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 55504.57 |
Authors | Steegborn, C.,Quast, J. (deposition date: 2021-06-14, release date: 2021-10-06, Last modification date: 2024-01-31) |
Primary citation | Fushimi, M.,Buck, H.,Balbach, M.,Gorovyy, A.,Ferreira, J.,Rossetti, T.,Kaur, N.,Levin, L.R.,Buck, J.,Quast, J.,van den Heuvel, J.,Steegborn, C.,Finkin-Groner, E.,Kargman, S.,Michino, M.,Foley, M.A.,Miller, M.,Liverton, N.J.,Huggins, D.J.,Meinke, P.T. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). Acs Med.Chem.Lett., 12:1283-1287, 2021 Cited by PubMed: 34413957DOI: 10.1021/acsmedchemlett.1c00273 PDB entries with the same primary citation |
Experimental method |
Structure validation
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