7OUH
Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir
Summary for 7OUH
Entry DOI | 10.2210/pdb7ouh/pdb |
EMDB information | 13077 |
Descriptor | Integrase, PC4 and SFRS1-interacting protein,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), ... (8 entities in total) |
Functional Keywords | integrase, intasome, htlv, stlv, integration, strand-transfer inhibitors, insti, bictegravir, bic, drug, viral protein |
Biological source | Simian T-lymphotropic virus 1 More |
Total number of polymer chains | 10 |
Total formula weight | 333452.07 |
Authors | Barski, M.S.,Ballandras-Colas, A.,Cronin, N.B.,Pye, V.E.,Cherepanov, P.,Maertens, G.N. (deposition date: 2021-06-11, release date: 2021-08-18, Last modification date: 2024-07-17) |
Primary citation | Barski, M.S.,Vanzo, T.,Zhao, X.Z.,Smith, S.J.,Ballandras-Colas, A.,Cronin, N.B.,Pye, V.E.,Hughes, S.H.,Burke Jr., T.R.,Cherepanov, P.,Maertens, G.N. Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nat Commun, 12:4996-4996, 2021 Cited by PubMed: 34404793DOI: 10.1038/s41467-021-25284-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)