7OTX
HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-257
Summary for 7OTX
Entry DOI | 10.2210/pdb7otx/pdb |
Related | 7OT6 7OTA 7OTK 7OTN |
Descriptor | Reverse transcriptase/ribonuclease H, DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), ... (7 entities in total) |
Functional Keywords | reverse transcriptase, rt inhibitor complex, acyclic nucleoside phosphonate analog, rt-dna complex, transferase |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 8 |
Total formula weight | 258207.68 |
Authors | Martinez, S.E.,Singh, A.K.,Gu, W.,Das, K. (deposition date: 2021-06-10, release date: 2021-12-08, Last modification date: 2024-01-31) |
Primary citation | Gu, W.,Martinez, S.,Singh, A.K.,Nguyen, H.,Rozenski, J.,Schols, D.,Herdewijn, P.,Das, K.,De Jonghe, S. Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225:113785-113785, 2021 Cited by PubMed: 34425311DOI: 10.1016/j.ejmech.2021.113785 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.45 Å) |
Structure validation
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