7OTH

PARP15 catalytic domain in complex with OUL219

Summary for 7OTH

• Entry DOI: 10.2210/pdb7oth/pdb
• Related: 7OQQ 7OSP 7OSS 7OSX 7OTF
• Descriptor: Protein mono-ADP-ribosyltransferase PARP15, 8-propan-2-yloxy-4~{H}-thieno[2,3-c]isoquinolin-5-one, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, adp-ribosyl-transferase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 51216.38

Authors

Maksimainen, M.M.,Lehtio, L. (deposition date: 2021-06-10, release date: 2021-12-08, Last modification date: 2024-01-31)

• Primary citation: Maksimainen, M.M.,Murthy, S.,Sowa, S.T.,Galera-Prat, A.,Rolina, E.,Heiskanen, J.P.,Lehtio, L.; Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs.; Bioorg.Med.Chem., 52:116511-116511, 2021; PubMed: 34801828; DOI: 10.1016/j.bmc.2021.116511

Experimental method

X-RAY DIFFRACTION (1.7 Å)