7OTE

Src Kinase Domain in complex with ponatinib

Summary for 7OTE

Entry DOI	10.2210/pdb7ote/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
Functional Keywords	atp inhibitor, kinase, ligand binding, cell signalling, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	69279.08
Authors	Soriano-Maldonado, P.,Cuesta-Hernandez, H.N.,Plaza-Menacho, I. (deposition date: 2021-06-10, release date: 2022-06-22, Last modification date: 2024-03-27)
Primary citation	Cuesta-Hernandez, H.N.,Contreras, J.,Soriano-Maldonado, P.,Sanchez-Wandelmer, J.,Yeung, W.,Martin-Hurtado, A.,Munoz, I.G.,Kannan, N.,Llimargas, M.,Munoz, J.,Plaza-Menacho, I. An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function. Nat Commun, 14:6548-6548, 2023 Cited by PubMed: 37848415 DOI: 10.1038/s41467-023-41890-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation