7OTE

Src Kinase Domain in complex with ponatinib

7OTE の概要

• エントリーDOI: 10.2210/pdb7ote/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
• 機能のキーワード: atp inhibitor, kinase, ligand binding, cell signalling, oncoprotein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69279.08

構造登録者

Soriano-Maldonado, P.,Cuesta-Hernandez, H.N.,Plaza-Menacho, I. (登録日: 2021-06-10, 公開日: 2022-06-22, 最終更新日: 2024-03-27)

• 主引用文献: Cuesta-Hernandez, H.N.,Contreras, J.,Soriano-Maldonado, P.,Sanchez-Wandelmer, J.,Yeung, W.,Martin-Hurtado, A.,Munoz, I.G.,Kannan, N.,Llimargas, M.,Munoz, J.,Plaza-Menacho, I.; An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.; Nat Commun, 14:6548-6548, 2023; PubMed: 37848415; DOI: 10.1038/s41467-023-41890-7

実験手法

X-RAY DIFFRACTION (2.49 Å)