7ORF

Crystal structure of JNK3 in complex with FMU-001-367 (compound 1)

7ORF の概要

• エントリーDOI: 10.2210/pdb7orf/pdb
• 分子名称: Mitogen-activated protein kinase 10, N-[4-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]phenyl]-3-(propanoylamino)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: kinase, mapk, mapk10, light activation, covalent inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44164.02

構造登録者

Chaikuad, A.,Koch, P.,Laufer, S.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2021-06-05, 公開日: 2021-07-21, 最終更新日: 2024-01-31)

• 主引用文献: Reynders, M.,Chaikuad, A.,Berger, B.T.,Bauer, K.,Koch, P.,Laufer, S.,Knapp, S.,Trauner, D.; Controlling the Covalent Reactivity of a Kinase Inhibitor with Light.; Angew.Chem.Int.Ed.Engl., 60:20178-20183, 2021; PubMed: 34081840; DOI: 10.1002/anie.202103767

実験手法

X-RAY DIFFRACTION (1.7 Å)