7ORB
Crystal structure of the L452R mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-75 and COVOX-253 Fabs
Summary for 7ORB
Entry DOI | 10.2210/pdb7orb/pdb |
Descriptor | Spike protein S1, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (16 entities in total) |
Functional Keywords | sars-cov-2 b.1.1.7 variant, b.1.351 variant, p.1 variant, b.1.617 variant, antibody, receptor-binding-domain, spike, neutralisation, viral protein/immune system, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) More |
Total number of polymer chains | 10 |
Total formula weight | 243812.59 |
Authors | Zhou, D.,Ren, J.,Stuart, D.I. (deposition date: 2021-06-04, release date: 2021-07-07, Last modification date: 2024-01-31) |
Primary citation | Liu, C.,Ginn, H.M.,Dejnirattisai, W.,Supasa, P.,Wang, B.,Tuekprakhon, A.,Nutalai, R.,Zhou, D.,Mentzer, A.J.,Zhao, Y.,Duyvesteyn, H.M.E.,Lopez-Camacho, C.,Slon-Campos, J.,Walter, T.S.,Skelly, D.,Johnson, S.A.,Ritter, T.G.,Mason, C.,Costa Clemens, S.A.,Gomes Naveca, F.,Nascimento, V.,Nascimento, F.,Fernandes da Costa, C.,Resende, P.C.,Pauvolid-Correa, A.,Siqueira, M.M.,Dold, C.,Temperton, N.,Dong, T.,Pollard, A.J.,Knight, J.C.,Crook, D.,Lambe, T.,Clutterbuck, E.,Bibi, S.,Flaxman, A.,Bittaye, M.,Belij-Rammerstorfer, S.,Gilbert, S.C.,Malik, T.,Carroll, M.W.,Klenerman, P.,Barnes, E.,Dunachie, S.J.,Baillie, V.,Serafin, N.,Ditse, Z.,Da Silva, K.,Paterson, N.G.,Williams, M.A.,Hall, D.R.,Madhi, S.,Nunes, M.C.,Goulder, P.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R. Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum. Cell, 184:4220-4236.e13, 2021 Cited by PubMed: 34242578DOI: 10.1016/j.cell.2021.06.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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