7ORA

Crystal structure of the T478K mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-45 and COVOX-253 Fabs

7ORA の概要

• エントリーDOI: 10.2210/pdb7ora/pdb
• 関連するPDBエントリー: 7OR9 7ORB
• 分子名称: Spike protein S1, COVOX-45 Fab heavy chain, COVOX-45 Fab light chain, ... (10 entities in total)
• 機能のキーワード: sars-cov-2 b.1.1.7 variant, b.1.351 variant, p.1 variant, b.1.617 variant, antibody, receptor-binding-domain, spike, neutralisation, viral protein/immune system, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 239552.13

構造登録者

Zhou, D.,Ren, J.,Stuart, D.I. (登録日: 2021-06-04, 公開日: 2021-07-07, 最終更新日: 2024-01-31)

• 主引用文献: Liu, C.,Ginn, H.M.,Dejnirattisai, W.,Supasa, P.,Wang, B.,Tuekprakhon, A.,Nutalai, R.,Zhou, D.,Mentzer, A.J.,Zhao, Y.,Duyvesteyn, H.M.E.,Lopez-Camacho, C.,Slon-Campos, J.,Walter, T.S.,Skelly, D.,Johnson, S.A.,Ritter, T.G.,Mason, C.,Costa Clemens, S.A.,Gomes Naveca, F.,Nascimento, V.,Nascimento, F.,Fernandes da Costa, C.,Resende, P.C.,Pauvolid-Correa, A.,Siqueira, M.M.,Dold, C.,Temperton, N.,Dong, T.,Pollard, A.J.,Knight, J.C.,Crook, D.,Lambe, T.,Clutterbuck, E.,Bibi, S.,Flaxman, A.,Bittaye, M.,Belij-Rammerstorfer, S.,Gilbert, S.C.,Malik, T.,Carroll, M.W.,Klenerman, P.,Barnes, E.,Dunachie, S.J.,Baillie, V.,Serafin, N.,Ditse, Z.,Da Silva, K.,Paterson, N.G.,Williams, M.A.,Hall, D.R.,Madhi, S.,Nunes, M.C.,Goulder, P.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R.; Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum.; Cell, 184:4220-4236.e13, 2021; PubMed: 34242578; DOI: 10.1016/j.cell.2021.06.020

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