7OR1

Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1

Summary for 7OR1

• Entry DOI: 10.2210/pdb7or1/pdb
• EMDB information: 13037
• Descriptor: Transient receptor potential cation channel subfamily A member 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ~{N}-[4-[4-[(azanylidene-$l^{4}-azanylidene)amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide, ... (8 entities in total)
• Functional Keywords: transient receptor potential cation channel subfamily a member 1, membrane protein, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 527319.24

Authors

Grieben, M.,Pike, A.C.W.,Saward, B.G.,Wang, D.,Mukhopadhyay, S.M.M.,Moreira, T.,Chalk, R.,MacLean, E.M.,Marsden, B.D.,Burgess-Brown, N.A.,Bountra, C.,Schofield, C.J.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2021-06-04, release date: 2022-06-22, Last modification date: 2024-11-13)

• Primary citation: Grieben, M.,Saward, B.G.,Pike, A.C.W.,Schofield, C.J.,Carpenter, E.P.; Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60; TO BE PUBLISHED,

Experimental method

ELECTRON MICROSCOPY (2.64 Å)