7OQQ
PARP15 catalytic domain in complex with TIQ-A
Summary for 7OQQ
Entry DOI | 10.2210/pdb7oqq/pdb |
Descriptor | Protein mono-ADP-ribosyltransferase PARP15, DIMETHYL SULFOXIDE, 4H-thieno[2,3-c]isoquinolin-5-one, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, adp-ribosyl-transferase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 45856.53 |
Authors | Maksimainen, M.M.,Lehtio, L. (deposition date: 2021-06-04, release date: 2021-12-08, Last modification date: 2024-01-31) |
Primary citation | Maksimainen, M.M.,Murthy, S.,Sowa, S.T.,Galera-Prat, A.,Rolina, E.,Heiskanen, J.P.,Lehtio, L. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg.Med.Chem., 52:116511-116511, 2021 Cited by PubMed: 34801828DOI: 10.1016/j.bmc.2021.116511 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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