7OQL

Crystal structure of the human METTL3-METTL14 complex with compound UOZ094

7OQL の概要

• エントリーDOI: 10.2210/pdb7oql/pdb
• 分子名称: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, (3~{R})-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-3-[[[6-[[(3~{S})-3-propan-2-yl-2-azoniaspiro[3.3]heptan-2-yl]methyl]naphthalen-1-yl]amino]methyl]piperidin-3-ol, ... (5 entities in total)
• 機能のキーワード: mettl3, inhibitor, complex, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62416.18

構造登録者

Bedi, R.K.,Huang, D.,Caflisch, A. (登録日: 2021-06-03, 公開日: 2021-10-20, 最終更新日: 2024-02-07)

• 主引用文献: Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A.; Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3; Acs Bio Med Chem Au, 2023; DOI: 10.1021/acsbiomedchemau.3c00023

実験手法

X-RAY DIFFRACTION (2.5 Å)