7OPP

Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug targeting

Summary for 7OPP

Entry DOI	10.2210/pdb7opp/pdb
Descriptor	Synaptotagmin-like protein 2,Ras-related protein Rab-27A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	rab27, gtpase, slp2a, exosome, exocytosis
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	53005.37
Authors	Jamshidiha, M.,Tersa, M.,Lanyon-Hogg, T.,Perez-Dorado, I.,Sutherell, C.L.,De Vita, E.,Morgan, R.M.L.,Tate, E.W.,Cota, E. (deposition date: 2021-06-01, release date: 2022-04-06, Last modification date: 2024-01-31)
Primary citation	Jamshidiha, M.,Lanyon-Hogg, T.,Sutherell, C.L.,Craven, G.B.,Tersa, M.,De Vita, E.,Brustur, D.,Perez-Dorado, I.,Hassan, S.,Petracca, R.,Morgan, R.M.,Sanz-Hernandez, M.,Norman, J.C.,Armstrong, A.,Mann, D.J.,Cota, E.,Tate, E.W. Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. Rsc Med Chem, 13:150-155, 2022 Cited by PubMed: 35308027 DOI: 10.1039/d1md00225b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation