7OOW

Crystal structure of PIM1 in complex with ARC-1415

7OOW の概要

• エントリーDOI: 10.2210/pdb7oow/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002339 PRD_002350
• 分子名称: Serine/threonine-protein kinase pim-1, INHIBITOR ARC-1415, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: pim1, inhibitor, kinase, kinase substrate, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37177.70

構造登録者

Chaikuad, A.,Dixon-Clarke, S.E.,Nonga, O.E.,Uri, A.,Bullock, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2021-05-28, 公開日: 2021-08-04, 最終更新日: 2024-04-10)

• 主引用文献: Nonga, O.E.,Lavogina, D.,Enkvist, E.,Kestav, K.,Chaikuad, A.,Dixon-Clarke, S.E.,Bullock, A.N.,Kopanchuk, S.,Ivan, T.,Ekambaram, R.,Viht, K.,Knapp, S.,Uri, A.; Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.; Molecules, 26:-, 2021; PubMed: 34299628; DOI: 10.3390/molecules26144353

実験手法

X-RAY DIFFRACTION (1.95 Å)