7OM1

Tankyrase 2 in complex with an inhibitor (OUL220)

This is a non-PDB format compatible entry.

Summary for 7OM1

• Entry DOI: 10.2210/pdb7om1/pdb
• Descriptor: Poly [ADP-ribose] polymerase tankyrase-2, 8-methoxy-4~{H}-thieno[2,3-c]isoquinolin-5-one, ZINC ION, ... (7 entities in total)
• Functional Keywords: inhibitor, enzyme, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 50853.98

Authors

Sowa, S.T.,Lehtio, L. (deposition date: 2021-05-21, release date: 2021-12-08, Last modification date: 2024-01-31)

• Primary citation: Maksimainen, M.M.,Murthy, S.,Sowa, S.T.,Galera-Prat, A.,Rolina, E.,Heiskanen, J.P.,Lehtio, L.; Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs.; Bioorg.Med.Chem., 52:116511-116511, 2021; PubMed: 34801828; DOI: 10.1016/j.bmc.2021.116511

Experimental method

X-RAY DIFFRACTION (1.7 Å)