7OFL

Crystal structure of the sesquiterpene synthase Copu9 from coniophora puteana in complex with alendronate

7OFL の概要

• エントリーDOI: 10.2210/pdb7ofl/pdb
• 分子名称: Terpene synthase, 4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: terpene synthase, sesquiterpene, cyclase, terpenoid, lyase
• 由来する生物種: Coniophora puteana (strain RWD-64-598) (Brown rot fungus)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87119.49

構造登録者

Dimos, N.,Loll, B. (登録日: 2021-05-05, 公開日: 2022-03-16, 最終更新日: 2024-01-31)

主引用文献

Ringel, M.,Dimos, N.,Himpich, S.,Haack, M.,Huber, C.,Eisenreich, W.,Schenk, G.,Loll, B.,Bruck, T.
Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of delta-cadinol.
Microb Cell Fact, 21:64-64, 2022

PubMed Abstract: Terpene synthases are versatile catalysts in all domains of life, catalyzing the formation of an enormous variety of different terpenoid secondary metabolites. Due to their diverse bioactive properties, terpenoids are of great interest as innovative ingredients in pharmaceutical and cosmetic applications. Recent advances in genome sequencing have led to the discovery of numerous terpene synthases, in particular in Basidiomycota like the wood rotting fungus Coniophora puteana, which further enhances the scope for the manufacture of terpenes for industrial purposes.

PubMed: 35440053
DOI: 10.1186/s12934-022-01791-8

実験手法

X-RAY DIFFRACTION (1.83 Å)