7O83

KRasG12C ligand complex

Summary for 7O83

• Entry DOI: 10.2210/pdb7o83/pdb
• Descriptor: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: inhibitor complex, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 40089.93

Authors

Phillips, C.,Breed, J. (deposition date: 2021-04-14, release date: 2022-04-20, Last modification date: 2022-05-25)

• Primary citation: Kettle, J.G.,Bagal, S.K.,Bickerton, S.,Bodnarchuk, M.S.,Boyd, S.,Breed, J.,Carbajo, R.J.,Cassar, D.J.,Chakraborty, A.,Cosulich, S.,Cumming, I.,Davies, M.,Davies, N.L.,Eatherton, A.,Evans, L.,Feron, L.,Fillery, S.,Gleave, E.S.,Goldberg, F.W.,Hanson, L.,Harlfinger, S.,Howard, M.,Howells, R.,Jackson, A.,Kemmitt, P.,Lamont, G.,Lamont, S.,Lewis, H.J.,Liu, L.,Niedbala, M.J.,Phillips, C.,Polanski, R.,Raubo, P.,Robb, G.,Robinson, D.M.,Ross, S.,Sanders, M.G.,Tonge, M.,Whiteley, R.,Wilkinson, S.,Yang, J.,Zhang, W.; Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .; J.Med.Chem., 65:6940-6952, 2022; PubMed: 35471939; DOI: 10.1021/acs.jmedchem.2c00369

Experimental method

X-RAY DIFFRACTION (2.38 Å)