7O7K
Crystal structure of the human DYRK1A kinase domain bound to abemaciclib
Summary for 7O7K
Entry DOI | 10.2210/pdb7o7k/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, CITRATE ANION, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine, ... (7 entities in total) |
Functional Keywords | serine/threonine kinase, cmgc kinase, dual specificity tyrosine-phosphorylation-regulated kinase 1a, dyrk1a, transcription, abemaciclib, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 87294.02 |
Authors | Kaltheuner, I.H.,Anand, K.,Geyer, M. (deposition date: 2021-04-13, release date: 2021-11-24, Last modification date: 2024-10-09) |
Primary citation | Kaltheuner, I.H.,Anand, K.,Moecking, J.,Duster, R.,Wang, J.,Gray, N.S.,Geyer, M. Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. Nat Commun, 12:6607-6607, 2021 Cited by PubMed: 34785661DOI: 10.1038/s41467-021-26935-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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